Liverpool versus Tottenham Hotspur is one of five Tuesday night matches, and the Anfield clash will be screened live on Sky Sports with a 7:45pm kick-off.
Arsenal and Reading meet at the Emirates Stadium, four years on from one of the greatest games in EFL Cup history.
At the Madejski Stadium, in 2012, Reading raced into a 4-0 lead, but were pegged back by the Gunners, who went on to book their Quarter-Final place with a 7-5 extra-time victory.
Elsewhere on Tuesday, Bristol City take on Hull City, while there are two all-Championship affairs. Newcastle United host Preston North End, with both teams unbeaten in six matches, while Leeds United welcome Norwich City to Elland Road.
The action concludes on Wednesday, with the small matter of a Manchester derby taking place at Old Trafford.
Red versus Blue. Mourinho versus Guardiola. Manchester United versus Manchester City. That game kicks off at 8pm, and is the second of Sky Sports' Round Four live TV selections.
There's another battle between two rivals on Wednesday, when West Ham United host London foes Chelsea at the London Stadium, with Southampton taking on Sunderland in another all-Premier League affair.
The EFL Cup Quarter-Final draw will take place following the conclusion of the Manchester derby, and can be viewed live on Sky Sports.
Draw: Click here for EFL Cup Quarter-Final draw detailsEFL Cup Round Four ties (all 7.45pm kick-off unless stated):Tuesday 25th October 2016
Liverpool v Tottenham Hotspur (live on Sky Sports)
Bristol City v Hull City
Leeds United v Norwich City
Newcastle United v Preston North End
Arsenal v Reading
Wednesday 26th October 2016
West Ham United v Chelsea
Southampton v Sunderland
Manchester United v Manchester City (8pm - live on Sky Sports)
Referees: Click here to see the match officials on Round Four dutyFollow, follow, follow...
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