Manchester United, Hull City, Southampton and Liverpool are the teams who will contest the semi-finals, and the first of the two-legged ties are now upon us.
Referees: Click here for the EFL Cup Semi-Final first leg match officialsSouthampton v Liverpool
The first leg between Southampton and Liverpool takes place on Wednesday, and the hosts will be hoping to avoid a repeat of last season's EFL Cup hammering at the hands of the eventual finalists.
Jurgen Klopp's first game in charge of the Reds came in this competition – a 1-0 win over Bournemouth – and they then hit the Saints for six at St Mary's in the following round.
Southampton's only scorer in that 6-1 loss, Saido Mane, is now a regular in Klopp's side, joining the likes of Nathaniel Clyne, Dejan Lovren and Adam Lallana in making the move to Merseyside from the south coast.
And while Liverpool have hit 12 goals on their way to this stage this time around, Claude Puel's men are yet to concede in the tournament, and kept the visitors at bay in a goalless Premier League draw in November.
Sofiane Boufal has stood out for Southampton in previous rounds along with some of the club's young stars, while teenage talents such as Trent Alexander-Arnold and Ben Woodburn have caught the eye for the Reds.
How they got here
Round Three: Crystal Palace (H) – 2-0
Round Four: Sunderland (H) – 1-0
Quarter-Finals: Arsenal (A) – 2-0
Round Two: Burton Albion (A) 5-0
Round Three: Derby County (A) 3-0
Round Four: Tottenham Hotspur (H) 2-1
Quarter-Finals: Leeds United (H) 2-0
Manchester United v Hull City (2-0 agg)
Old Trafford is the first port of call for the EFL Cup Semi-Finals, where Jose Mourinho's Manchester United welcome Hull City.
Mourinho is a three-time winner of the competition over two spells with Chelsea, and the silverware was the first he lifted after his move to England back in 2004.
In the opposite dugout tonight is another Portuguese boss, Marco Silva, who himself has just begun his first managerial task on these shores and now has the opportunity to mirror Mourinho's achievement.
The Tigers' record against United in unfavourable, however, with tonight's hosts winning 11 of the last 12 encounters, and Hull have won just once here in their history – a 1952 FA Cup triumph.
The Red Devils' top scorers in the tournament are Zlatan Ibrahimovic and Anthony Martial, who both bagged braces in the Quarter-Final, while Hull's Robert Snodgrass and Adama Diomande also have two goals apiece in the tournament.
How they got here
Round Three: Northampton Town (A) – 3-1
Round Four: Manchester City (H) – 1-0
Quarter-Finals: West Ham United (H) – 4-1
Round Two: Exeter City (A) – 1-3
Round Three: Stoke City (A) – 1-2
Round Four: Bristol City (A) – 1-2
Quarter-Finals: Newcastle United (H) – 1-1 (3-1 on penalties)
Follow the EFL Cup live!
Sky Sports will be screening the first legs of both EFL Cup Semi-Finals this week, with Southampton and Liverpool - a 7:45pm kick-off at St Mary's - being shown on Wednesday 11th January.
You can also keep up to speed with the EFL Cup by following us on Twitter
, and searching for the #EFLCup